GlucoKinaseDB (GKDB) is a manually curated database of glucokinase modulators. The data included in GKDB were retrieved from published articles, chemical data repositories and patent literature. Different classes of modulators are included in GKDB such as; Glucokinase activators (GKAs), GK-GKRP disruptors and Glucokinase inhibitors (GKIs). The database currently provides bioactivity and chemical information on a total of 1723 modulators. GKDB provides several features such as advanced search criteria, downloadable structures in multiple formats, in-browser visualization, cross-links to other chemical databases etc. Users may also submit data on novel modulators on the 'Submit' page for inclusion into GKDB.